The palladium catalyzed C-C bond forming reactions became a significant tool in modern synthetic chemistry (2010 Nobel Prize for Chemistry). Although the application of these chemical transformations are indispensable in both small-scale and process chemistry operations, they still suffer from many drawbacks:
We tested the storage stability of the SUPERSTABLE Pd(0) CATALYST under a controlled GLP environment (on air, temperature of 40 °C and humidity of 75%). After 20 months, no change of color was observed and also no detectable decomposition occurred according to the 1H-NMR, 19F-NMR and 31P-NMR. Instead of minutes or hours - as with previous palladium(0) catalysts - the SUPERSTABLE Pd(0) CATALYST can be stored for years exposed to air at room temperature without any detectable decomposition.
We performed two Suzuki model reactions in the mixture of MeOH-H2O (10:1) system at 110°C. After one hour, the conversions were complete and no palladium black formation occurred. In comparison, the analogous Pd(PPh3)4 resulted in a palladium black formation after a few minutes.
A Robust and Efficient Catalyst Possessing an Electron-Deficient Ligand
for the Palladium-Catalyzed Direct Arylation of Heteroarenes (European
Journal of Organic Chemistry 2015, 1, 56–59)
Alexandra Jakab, Zoltán Dalicsek and Tibor Soós
Superstable Palladium(0) Complex as an Air- and Thermostable Catalyst
for Suzuki Coupling Reactions, (European Journal of Organic Chemistry
2015, 1, 60–66)
Alexandra Jakab, Zoltán Dalicsek, Tamás Holczbauer, Andrea Hamza, Imre
Pápai, Zoltán Finta, Géza Timári and Tibor Soós
The Conversion of 4‑Anilinoquinazoline- and
Benzo[4,5]imidazo[1,2‑c]quinazoline-6-carbonitriles via Oxidative and
Nonoxidative C−N Couplings, (J. Org. Chem. 2015, 80, 8329−8340),
Styliana I. Mirallai and Panayiotis A. Koutentis